暫定対処

取り急ぎVS Codeを動くバージョンの1.65.2にダウン。Windows64はこちら　他はこちらみてバージョンを1.65.2にて適宜。

(2022/05/30追記)

また、こちらにあるようにForkされたPico-goをビルドしてもよい模様。

起きていたエラー

VS Codeの拡張機能エラーに下のが出ていた。

 → c:\Users\kitam\.vscode\extensions\chriswood.pico-go-1.4.3\node_modules\@serialport\bindings\lib\binding\node-v101-win32-x64\bindings.node
	at bindings (c:\Users\kitam\.vscode\extensions\chriswood.pico-go-1.4.3\node_modules\bindings\bindings.js:126:9)
	at Object.<anonymous> (c:\Users\kitam\.vscode\extensions\chriswood.pico-go-1.4.3\node_modules\@serialport\bindings\lib\win32.js:1:98)
	at Module.u._compile (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\loader.js:4:1313)
	at Object.Module._extensions..js (node:internal/modules/cjs/loader:1216:10)
	at Module.load (node:internal/modules/cjs/loader:1035:32)
	at Module._load (node:internal/modules/cjs/loader:876:12)
	at Function.c._load (node:electron/js2c/asar_bundle:5:13331)
	at Function.i._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:104:32156)
	at Function.E._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:104:28749)
	at Function.g._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:99:61429)
	at Module.require (node:internal/modules/cjs/loader:1059:19)
	at h (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\loader.js:4:699)
	at Object.<anonymous> (c:\Users\kitam\.vscode\extensions\chriswood.pico-go-1.4.3\node_modules\@serialport\bindings\lib\index.js:6:22)
	at Module.u._compile (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\loader.js:4:1313)
	at Object.Module._extensions..js (node:internal/modules/cjs/loader:1216:10)
	at Module.load (node:internal/modules/cjs/loader:1035:32)
	at Module._load (node:internal/modules/cjs/loader:876:12)
	at Function.c._load (node:electron/js2c/asar_bundle:5:13331)
	at Function.i._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:104:32156)
	at Function.E._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:104:28749)
	at Function.g._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:99:61429)
	at Module.require (node:internal/modules/cjs/loader:1059:19)
	at h (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\loader.js:4:699)
	at Object.<anonymous> (c:\Users\kitam\.vscode\extensions\chriswood.pico-go-1.4.3\node_modules\serialport\lib\index.js:2:17)
	at Module.u._compile (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\loader.js:4:1313)
	at Object.Module._extensions..js (node:internal/modules/cjs/loader:1216:10)
	at Module.load (node:internal/modules/cjs/loader:1035:32)
	at Module._load (node:internal/modules/cjs/loader:876:12)
	at Function.c._load (node:electron/js2c/asar_bundle:5:13331)
	at Function.i._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:104:32156)
	at Function.E._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:104:28749)
	at Function.g._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:99:61429)
	at Module.require (node:internal/modules/cjs/loader:1059:19)
	at h (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\loader.js:4:699)
	at Object.<anonymous> (c:\Users\kitam\.vscode\extensions\chriswood.pico-go-1.4.3\lib\connections\pyserial.js:20:19)
	at Module.u._compile (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\loader.js:4:1313)
	at Object.Module._extensions..js (node:internal/modules/cjs/loader:1216:10)
	at Module.load (node:internal/modules/cjs/loader:1035:32)
	at Module._load (node:internal/modules/cjs/loader:876:12)
	at Function.c._load (node:electron/js2c/asar_bundle:5:13331)
	at Function.i._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:104:32156)
	at Function.E._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:104:28749)
	at Function.g._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:99:61429)
	at Module.require (node:internal/modules/cjs/loader:1059:19)
	at h (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\loader.js:4:699)
	at Object.<anonymous> (c:\Users\kitam\.vscode\extensions\chriswood.pico-go-1.4.3\lib\pymakr.js:18:17)
	at Module.u._compile (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\loader.js:4:1313)
	at Object.Module._extensions..js (node:internal/modules/cjs/loader:1216:10)
	at Module.load (node:internal/modules/cjs/loader:1035:32)
	at Module._load (node:internal/modules/cjs/loader:876:12)
	at Function.c._load (node:electron/js2c/asar_bundle:5:13331)
	at Function.i._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:104:32156)
	at Function.E._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:104:28749)
	at Function.g._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:99:61429)
	at Module.require (node:internal/modules/cjs/loader:1059:19)
	at h (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\loader.js:4:699)
	at Object.<anonymous> (c:\Users\kitam\.vscode\extensions\chriswood.pico-go-1.4.3\lib\activator.js:28:15)
	at Module.u._compile (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\loader.js:4:1313)
	at Object.Module._extensions..js (node:internal/modules/cjs/loader:1216:10)
	at Module.load (node:internal/modules/cjs/loader:1035:32)
	at Module._load (node:internal/modules/cjs/loader:876:12)
	at Function.c._load (node:electron/js2c/asar_bundle:5:13331)
	at Function.i._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:104:32156)
	at Function.E._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:104:28749)
	at Function.g._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:99:61429)
	at Module.require (node:internal/modules/cjs/loader:1059:19)
	at h (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\loader.js:4:699)
	at Object.<anonymous> (c:\Users\kitam\.vscode\extensions\chriswood.pico-go-1.4.3\pymakr.js:1:81)
	at Module.u._compile (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\loader.js:4:1313)
	at Object.Module._extensions..js (node:internal/modules/cjs/loader:1216:10)
	at Module.load (node:internal/modules/cjs/loader:1035:32)
	at Module._load (node:internal/modules/cjs/loader:876:12)
	at Function.c._load (node:electron/js2c/asar_bundle:5:13331)
	at Function.i._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:104:32156)
	at Function.E._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:104:28749)
	at Function.g._load (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:99:61429)
	at Module.require (node:internal/modules/cjs/loader:1059:19)
	at require (node:internal/modules/cjs/helpers:102:18)
	at Function.r [as __$__nodeRequire] (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\loader.js:5:101)
	at u._loadCommonJSModule (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:104:30318)
	at u._doActivateExtension (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:90:13361)
	at u._activateExtension (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:90:12313)
	at processTicksAndRejections (node:internal/process/task_queues:96:5)
	at async g._activate (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:85:8154)
	at async g._waitForDepsThenActivate (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:85:8096)
	at async g._initialize (c:\Users\kitam\AppData\Local\Programs\Microsoft VS Code\resources\app\out\vs\workbench\api\node\extensionHostProcess.js:85:7460)

isuueとか見るとVS Codeが1.66になったときにNodeのバージョンも変わって不整合でテイルっぽい。